Jose Mourinho warned of a dangerous tie poised 1-1 after the first leg in Istanbul three weeks ago, but four minutes into the second leg his side regained the advantage before advancing into Friday's last-eight draw with ease, 3-1 on aggregate.
Drogba, scorer of 157 goals in 341 appearances over eight years for the Blues, including the decisive penalty in the 2012 European Cup win, was expected to be the main protagonist of the contest.
But it was another 30-something African striker who found the net with the first attack as, for once, the Ivorian faded into the background on the big occasion, with Eden Hazard the outstanding forward on display.
Samuel Eto'o showed his predatory instinct to fire the Blues in front at the end of a move started by Hazard and Gary Cahill added a second before the interval to give Chelsea a commanding two-goal advantage.
Chelsea were unable to add to their tally, but did not need to.
Roberto Mancini's visitors were a distant second best throughout and offered up little resistance as the former Manchester City manager's return to England ended in a limp loss.
Given Manchester United and Tottenham face two-goal deficits - on Wednesday against Olympiacos in the Champions League and on Thursday at Benfica in the Europa League, respectively - it is possible Chelsea will be the only English club in Europe come Friday's draws.
Their immediate attention now turns to Saturday's Premier League showdown with Arsenal, where Mourinho's leaders will hope to put the controversial loss at Aston Villa firmly in the past in Arsene Wenger's 1000th game as Gunners boss.
Wenger was branded a "specialist in failure" by Mourinho last month.
Source : PA
Source: PA