At just 33, the Portuguese coach will be the youngest boss in the Premier League next season, having been appointed successor to experienced Italian Carlo Ancelotti.
It has been suggested the former Porto manager, who guided the Dragons to domestic and Europa League success last season, will find it difficult to command respect among the older squad members.
However, England defender Cole, 30, feels Villas-Boas - no stranger to many players from his time at Stamford Bridge as a part of Jose Mourinho's backroom staff - will soon settle into his new role.
"Age is just a number, he has experience of being at Porto, a big club," Cole said in an interview with Sky Sports News.
"Hopefully he can bring that glory to Chelsea, but I don't think the age thing is anything to worry about, I don't think the players think about that. He is our manager now and we have to go out and fight for him.
"Whatever manager comes in we respect him, we are not kids, everyone thinks there are egos at Chelsea, but there aren't and we have to make Chelsea the squad of a few years ago and win trophies."
Chelsea players will return to the Cobham training ground for the start of pre-season training this week, with Villas-Boas maintaining there would be no immediate transfers or new arrivals until he had time to fully assess the current group, with a tour to the Far East ahead of the Asia Trophy coming up.
Brazil international Neymar, Anderlecht's 18-year-old Belgium striker Romelu Lukaku, Tottenham's Croatian midfielder Luka Modric as well as Porto duo Radamel Falcao and Joao Moutinho are all reported targets.
By the time the new Premier League campaign kicks off at Stoke, there are likely to be a couple of new faces and Cole feels that can only help Chelsea's ambitions on all fronts.
"We just fell short last season, we had a lot of injuries so hopefully if we do bring players in we can strengthen the squad and kick on because we've got so many great players at Chelsea that we should be winning the league two times on the trot, which we didn't," said the England full-back.
"I think all teams would love to see fresh faces, but the age thing, it creeps up on players and as you get older you get knocks more and things like that. But they're very professional players at Chelsea and if we can add to that with maybe some younger players I don't see why we can't improve on last season and win the league, win the Champions League and win the FA Cup because we've got the players to do it.
"A lot of players' dreams are to win the Champions League. I have played in two finals, but of course we want to win - but we want to win any trophy."
Cole found himself in the front-page headlines earlier this year for an incident at the training ground when a work placement student was shot with an air rifle, while the relationship with his former wife Cheryl Cole continues to attract attention.
The defender, however, will not let those issues see him lose focus.
"I have made mistakes and have just got to live with it," Cole added in an interview with BBC Sport.
"I just wish people would judge me more on football and speak about football more than a life that people don't really know."
Cole continued: "If someone had actually seen the [shooting] incident - you wouldn't laugh because it was a stupid thing to do - but the whole situation was crazy. Of course it was an accident.
"But if I wanted to address every single thing in the paper I'd lose my mind. It makes me crazy now when I hear things.
"But like I say, you've just got to deal with it. I'm just here to play football. That's all I want to do."
Source: Team Talk
Source: Team Talk