The Blues have to overcome Benfica first - and Barcelona do the same against Milan - if a repeat of the 2009 semi-final is to happen - and Di Matteo insists his side will be completely focused on the Portuguese side.
Asked about a possible meeting with the reigning European champions, Di Matteo said: "Are you writing off AC Milan straight away, as easy as that - the leaders of Serie A?."
He added: "It's game by game. That's what I've learnt in my playing career and managing and coaching career."
"When you get down to the last eight teams, every draw is very difficult. I've seen Benfica many times. They were in Manchester United's group and they are a tough opponent for us. I think the fact that we play the first game away from home is good, a little bit like the Napoli game."
In the other quarter-finals, Real Madrid were drawn against Cyprus side APOEL while Marseille will take on Bayern Munich. The draw also means there is a chance of the ultimate El Clasico happening - a mouthwatering all-Spanish final between Real and Barcelona.
Chelsea, England's last remaining club in Europe, have two former Benfica players in their squad - the Brazilians David Luiz and Ramires.
The Portuguese club are currently second in their domestic league, a point behind Porto, and overcame a 3-2 first-leg defeat by Zenit St Petersburg in the first knock-out stage, winning 2-0 at the Estadio da Luz to secure their place in the quarter-finals.
Chelsea's old guard came to the club's rescue against Napoli on Wednesday night with John Terry, Frank Lampard and Didier Drogba all scoring in a 4-1 win and the club's chief executive Ron Gourlay said a blend of experience and youth was vital.
He told the club's website: "You need experience, you need youth and you need a little bit of luck. Any team that has won it will tell you this, hopefully we get that but let's worry about Benfica, give them the respect they deserve and take it from there."
Source: PA
Source: PA