Frank Lampard, Didier Drogba, Michael Ballack and Deco are out for the league clash against Wolves tomorrow.
Joe Cole, Mikel, Florent Malouda and Salomon Kalou will replace them.
Gael Kauta Fabio Borini, Nemanja Matic will replace them on the substitute bench.
John Terry is fit to return following his absence from Saturday's England defeat against Brazil. Also back is Ashley Cole.
Chelsea coach Carlo Ancelotti expects Deco, Ballack and Drogba to be fit for next Wednesday's away Champions' League clash against Porto.
Lampard is out for at least two more weeks.