Lampard has a scan today on a rib problem and the result showed the midfielder would not be able to train or play in the friendly encounter.
However John Terry is expected to play and continue to skipper the side.
He picked up a knock in the 3-0 win at West Brom on Saturday but trained with the England squad today.
England are already without Ashley Cole and Joe Cole. Wayne Bridge is expected to play, while on-loan centre-back Michael Mancienne is included in the squad.
The U-21 star is at high-flying Wolves at the moment and will gain vital top-class experience.