Just 24 hours after Manchester United emerged from their game at Highbury to be Chelsea's only real challengers for the title, Jose Mourinho's side extended their lead at the top of the table to 11 points thanks to Arjen Robben's early goal.
The Dutchman drilled his 20-yard shot under the body of Brad Friedel in the fifth minute for what proved to be the winner after he had latched on to an Eidur Gudjohnsen header and beaten Ryan Nelson
Rovers wasted the prefect chance to equalise on the hour when Paulo Ferreira tripped Robbie Savage but Petr Cech saved brilliantly from Paul Dickov's spot-kick.
The save means the Czech international beats Peter Schmeichel's record for the longest run without conceding a Premiership goal.
The 22-year-old's record now stands at an unbelievable 781 minutes.
Damien Duff forced Friedel into a good save after the breakthrough goal but when Blackburn hit back Andy Todd headed wide before Savage went close twice in a minute.
Chelsea looked comfortable after the break as they easily soaked up the Blackburn pressure and hit their hosts on the counter-attack.
Cole and Frank Lampard both went close while their rock-solid defence never looked like being breached.
Dickov went close in the last few minutes but the Blues hung on to clinch their eighth Premiership win in a row.