No-one can now be in any doubt that the squad assembled by Jose Mourinho deserved the back-to-back titles only achieved previously by United in the Premiership era.
Goals from William Gallas, Joe Cole and Ricardo Carvalho sent the 42,219 Chelsea fans into delirium.
Even before the final whistle, Mourinho and his staff were up off the bench and dancing down the touchline.
With just a point needed to clinch the title, Chelsea boss Mourinho restored wingers Cole and Arjen Robben to his side from the one which lost the FA Cup semi-final last Saturday to Liverpool.
The positive team selection reaped its just rewards within five minutes of the start.
A Frank Lampard corner was powerfully headed towards goal by Didier Drogba and up popped left-back Gallas at United's right post to nod home unchallenged from four yards.
United striker Wayne Rooney's clumsy challenge on John Terry's shin after nine minutes saw the England defender prone on the ground for three minutes.
Thankfully for him, and England, he recovered quickly with only cuts on his foot from Rooney's boot studs. But the Chelsea captain was at fault on 22 minutes when he allowed Rooney to skip past him and arrow towards goal.
Facing a one-on-one with Petr Cech, Rooney scuffed his shot wide of the Blues keeper and the goal.
Seconds later Robben found himself with the ball on the United by-line but his lofted cross just missed Drogba.
United's best effort of the half fell to Rooney on 42 minutes, but his right-footed daisy-cutter was well held by Cech.
John O'Shea produced a header right on the half-time whistle, but the ball went over the bar.
Cristiano Ronaldo fluffed a gilt-edged free-kick on 54 minutes and two minutes later Robben tried a speculative 25-yard effort that too sailed high and wide.
A minute later and the game was over as Cole delighted the Chelsea faithful with a sensational strike.
With his back to goal ten yards out, Cole back-heeled the ball, twisted around and raced towards goal. He then smashed a vicious right-footer past Edwin Van der Sar at his near post.
The third goal in the 73rd minute was a delight as Carvalho started a counter-attack and finished it himself in style.
Bringing the ball out of his own area the Portuguese defender fed Lampard. The midfielder passed the ball wide on the left to Carvalho who had continued his run. He took the ball inside the area and rammed home a powerful left-footed strike that left Van der Sar floundering.
Chelsea had won the title and United's misery was compounded ten minutes from time when Rooney was stretchered off with a foot injury and is now a doubt for England at this summer's World Cup.