Goals from Andriy Shevchenko, Salomon Kalou and Michael Ballack swept aside the opponents who are languishing close to the bottom of the league.
For Chelsea's part, the points keep the pressure on Manchester United with six points still the difference between the top two in the Premiership.
This training match for the Blues started in ideal fashion and the Londoners took just three minutes to open the scoring.
Centre-back Ricardo Carvalho broke into Sheffield United's half and chipped an inch-perfect ball to Shevchenko. The Ukraine striker was unmarked just inside the left-hand corner of the visitors' penalty area.
He cushioned the ball with his right leg and in one swift movement lashed home a vicious left-footer across the body of Paddy Kenny and the ball rifled into the top left-hand corner of his net.
Goal number two came 13 minutes later after Arjen Robben fed Shaun Wright-Phillips the ball on the right.
The winger sent in a curling ball, which was tapped across the goal-line by Shevchenko. At the far post up popped Kalou to tuck the ball home from six yards.
But Sheffield United almost rocked the Premiership champions on 19 minutes when Colin Kazim-Richards let fly from 20 yards and Petr Cech acrobatically blocked the goal-bound effort.
The Chelsea goalkeeper was in action two minutes later when he blocked a Rob Hulse shot with his legs.
The lone striker injured himself in collision with Cech and was replaced by Christian Nade on 27 minutes.
Claude Davis did puncture the Chelsea rearguard and found the net on 30 minutes, but unfortunately Kazim-Richards had strayed into an offside position.
Such was Chelsea's superiority that Jose Mourinho took the luxury of replacing Frank Lampard with Ballack at half-time.
The German captain's first contribution to the game was a smartly taken 30-yard drive on 54 minutes, but Kenny had the ball covered as it just zipped past his right post.
However, Ballack made no mistake four minutes later, when he headed from six yards a quickly taken left-wing free-kick by Wright-Phillips.
Didier Drogba and Paulo Ferreira replaced Shevchenko and Ashley Cole while United replaced Alan Quinn with Michael Tonge on 67 minutes.
Drogba hit an 81st minute free-kick which was headed off the line by midfielder Phil Jagielka.
Chelsea, with one eye on Monday's FA Cup replay at Spurs, then ran down the clock in comfortable style.