The Spanish side tried to give Chelsea a game and not to defend and were unlucky not to take something from the match after producing a fine first-half performance.
But Chelsea, on the counter-attack are in a different class, and on 24 minutes they took the lead.
Michael Essien, in central midfield, powered forward, intercepting a poor cross-field ball. He raced towards goal and then produced an inch-perfect, slide-rule pass to Didier Drogba.
The Ivory Coast striker took one touch of the ball, wide on the left side of the penalty area before slotting a low right-footer towards goal.
The ball went under goalkeeper Antonio Doblas and took a slight deflection off centre-back David Rivas before rattling the back of the net.
The comic goalkeeping came seconds before half-time. A whipped, curving free-kick by Frank Lampard, wide on the left by-passed all the players and flew straight into the hands of Doblas.
Inexplicably he dropped the ball on the goal-line and Ricardo Carvalho popped up to tap the ball home.
Betis did not deserve to be two goals behind at half-time.
They were a constant threat from set-pieces and forced goalkeeper Carlo Cudicini into several smart saves.
But they could not keep up the pressure in the second half, and they allowed Chelsea a lot of space to play.
The third goal came after 59 minutes and it was a beauty of individual proportions by England midfielder Joe Cole.
Again a quick counter-attack saw the ball pass through Claude Makelele, substitute Hernan Crespo and then Essien who fed the ball to Cole.
The midfielder raced towards goal, before bending a right-footer, wide around Rivas and ultimately the goalkeeper from 20 yards out into the keeper's left-hand corner of the net.
The game was dead from that point on but still the clinical instinct was evident in the Premiership champions and they killed off the Spanish challenge on 64 minutes.
This time it was sublime play from Shaun Wright-Philips. The right winger collected the ball wide on the right and raced to the byline where he produced a brilliant right-footed cross which arrowed across the six-yard box.
It was met beautifully, full on the head by a diving Crespo, in the centre of the goal. It gave Doblas no chance as it flew into the back of the net.